An IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2 (TRAM), Ticam1 (TRIF), TRAF3 linked to Lys-63 polyubiquitin, phosphorylated tbk1, and non-phosphorylated IRF3. IRF3 is recruited via phosphorylated tbk1.