About: tumor necrosis factor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : rdfs:Class, within Data Space : sparql.proconsortium.org associated with source document(s)

Category=gene.

AttributesValues
rdf:type
rdfs:subClassOf
rdfs:label
  • tumor necrosis factor
  • tumor necrosis factor
rdfs:comment
  • Category=gene.
rdfs:seeAlso
obo:id
  • PR:000000134
has_exact_synonym
  • TNF
  • TNF-a
  • TNF-alpha
  • TNFa
  • cachectin
  • tumor necrosis factor alpha
  • tumor necrosis factor ligand superfamily member 2
database_cross_reference
  • PIRSF:PIRSF500467
has_related_synonym
  • TNFA
  • TNFSF2
definition
  • A tumor necrosis factor, TNF-like that is a translation product of the human TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells.
has_obo_namespace
  • protein
skos:closeMatch
anyRelationship
  • [is_a] PR:000000033 ! tumor necrosis factor, TNF-like;
is rdfs:subClassOf of
is rdf:first of
is owl:annotatedSource of
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