About: TGF-beta superfamily receptor type-1

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About: TGF-beta superfamily receptor type-1 Goto Sponge NotDistinct Permalink

An Entity of Type : rdf:resource, within Data Space : sparql.proconsortium.org associated with source document(s)

Category=family.

Attributes	Values
rdf:type	Class rdf:resource
rdfs:subClassOf	protein
rdfs:label	TGF-beta superfamily receptor type-1
rdfs:comment	Category=family.
http://pir.georget...paf#objectSynonym	TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I (PTHR23255:SF15)
http://pir.georget...ro/paf#objectTerm	TGF-beta superfamily receptor type-1
obo:id	PR:000000006
database_cross_reference	PIRSF:PIRSF037391
has_broad_synonym	TGF-beta receptor type I TGF-beta type I receptor TGFR-1 TbetaR-I transforming growth factor-beta receptor type I
definition	A protein that is a translation product of an evolutionary-related gene with core domain composition consisting of an extracellular Activin types I and II receptor domain (Pfam:PF01064), a transmembrane domain, a Transforming growth factor beta type I GS-motif (Pfam:PF08515) and a Protein kinase domain (Pfam:PF00069). The transforming growth factor-beta (TGF-beta) superfamily of receptors comprises two groups of transmembrane serine-threonine kinase receptors, so called type-1, and type-2 receptors, that are activated following engagement by members of the TGF-beta superfamily of ligands. These events specify diverse downstream responses that are differentially regulated by controlling access and activation of the ligands, their receptors and downstream substrates in different cell types. The type 1 receptors are characterized by the presence of a glycine-serine rich juxta-membrane domain (the GS-motif) that is critical for their activation.
has_obo_namespace	protein
anyRelationship	[is_a] PR:000000001 ! protein;
is rdfs:subClassOf of	BMP receptor type-1A BMP receptor type-1B TGF-beta receptor type-1 activin receptor type-1 activin receptor type-1B activin receptor type-1C serine/threonine-protein kinase receptor R3
is rdf:subject of	nodeID://b10300525 nodeID://b10300528 nodeID://b10300531
is owl:annotatedSource of	nodeID://b10451606

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