About: IkappaB kinase complex     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : sparql.proconsortium.org associated with source document(s)

AttributesValues
rdf:type
rdfs:subClassOf
rdfs:label
  • IkappaB kinase complex
obo:id
  • GO:0008385
has_exact_synonym
  • heterotrimeric IKK complex
definition
  • A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
has_obo_namespace
  • cellular_component
anyRelationship
  • [is_a] GO:0032991 ! protein-containing complex;
is rdfs:subClassOf of
is owl:annotatedSource of
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